Browsing by Author "Olea Azar, Claudio"

Now showing items 1-20 of 137

    • 1,2,4-Triazine N-oxide derivatives: Studies as potential hypoxic cytotoxins. Part III 
      Cerecetto, Hugo; González, M.; Risso, Mariela; Saenz, P.; Olea Azar, Claudio; Bruno, A. M.; Azqueta, Amaia; De Cerain, A. L.; Monge, A. (WILEY-V C H VERLAG GMBH, 2004-05)
      New 5-(2-arylethenyl)-1,2,4-triazine N-oxide and N,N'-dioxide derivatives were synthesized in order to obtain compounds as selective hypoxic cell cytotoxins. The desired products were obtained when the 5-methyl heterocycle ...
    • A Computationally Efficient and Reliable Bond Order Measure 
      Mera, Raúl; Mendizábal Emaldía, Fernando; Olea Azar, Claudio; Miranda Rojas, Sebastián; Fuentealba Rosas, Patricio (AMER CHEMICAL SOC, 2011-05-05)
      Bond order indexes are useful measures that connect quantum mechanical results with chemical understanding. One of these measures, the natural bond order index, based on the natural resonance theory procedure and part of ...
    • Actividad inhibitoria sobre enzimas que regulan la glicemia y efecto antioxidante de una serie nueva de ... 
      Figueroa Benavides, Catalina Paz (Universidad de Chile, 2018)
      La diabetes mellitus de tipo dos (DMT2) es una enfermedad metabólica caracterizada por un incremento crónico de la glicemia y un desequilibrio oxidativo que a largo plazo conllevan a la aparición de una serie de ...
    • Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, ... 
      Castro, Diego; Boiani, Lucía; Benítez, Diego; Hernández, Paola; Merlino, Alicia; Gil, Carmen; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo; Porcal, Williams (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      Hybrid vinylthio-, vinylsulfinyl-, vinylsulfonyl- and vinylketo-benzofuroxans developed as anti-trypanosomatid agents, against Trypanosoma cruzi and Leishmania spp., have showed low micromolar IC50 values. The synthetic ...
    • Antioxidant activity of the mangiferin inclusion complex with beta-cyclodextrin 
      Rocha Ferreira, Fabricia da; Barros Valentim, Iara; Catarí Ramones, Edgar Luís; Salles Trevisan, Maria Teresa; Olea Azar, Claudio; Pérez Cruz, Fernanda; Caxico de Abreu, Fabiane; Fonseca Goulart, Marília Oliveira (Elsevier, 2012-09-28)
      The aim of this study was to characterize the complex between mangiferin (MGN) with beta-cyclodextrin (beta-CD) obtained through the co-evaporation method using Differential Scanning Calorimetry (DSC) and Fourier Transform ...
    • Antioxidant properties and free radical-scavenging reactivity of a family of hydroxynaphthalenones and ... 
      Rodríguez Borges, Jorge; Olea Azar, Claudio; Cavieres, C.; Norambuena, Ester; Delgado Castro, Tomás; Soto Delgado, Jorge; Araya Maturana, Ramiro (PERGAMON-ELSEVIER SCIENCE LTD, 2007-11-15)
      This study was undertaken to investigate the free radical -scavenging and antioxidant activities of various structurally related hydroquinones including hydroxynaplithalenones and dihydroxyanthracenones. Electron spin ...
    • Apoptosis induced by hyperosmotic stress 
      Eisner, Verónica; Quiroga Lagos, Clara; Criollo Céspedes, Alfredo; Olea Azar, Claudio; Díaz Araya, Guillermo; Chiong Lay, Mario; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 2004)
      Meeting Abstract
    • Applications of electron spin resonance and spin trapping in tropical parasitic diseases 
      Olea Azar, Claudio; Rigol, C.; Mendizábal Emaldía, Fernando; Briones, R. (2006)
      Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR ...
    • Applications of electron spin, resonance and spin trapping in tropical parasitic diseases 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo (BENTHAM SCIENCE PUBL LTD, 2006-02)
      Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR ...
    • Basis set effects on B3LYP geometries and energies: case study of interstellar reaction HN=CH2 + •C≡N → ... 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (2002)
      To facilitate a rational basis set selection for B3LYP studies of organic reactions in the interstellar medium, we analyzed energetic parameters for the main stationary points in the reaction HN=CH2 + •C≡N → H2N-C(•)H-C≡N ...
    • Biological and chemical study of fused tri- and tetracyclic indazoles and analogues with important antiparasitic ... 
      Díaz Urrutia, Christian; Olea Azar, Claudio; Zapata, Gerald A.; Lapier, Michel; Mura Mardones, Francisco; Aguilera Venegas, Benjamín; Arán, Vicente J.; López Muñoz, Rodrigo; Maya Arango, Juan (2012)
      A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic ...
    • Cathodic behavior of 2,3-dihydrooxoisoaporphines comportamiento catódico de 2,3-dihidro-oxoisoaporfinas 
      Sobarzo Sánchez, Eduardo; Olea Azar, Claudio; Alarcón, Jaime; Opazo, Lucía; Cassels Niven, Bruce (2003)
      The electrochemical behavior of two representative 2,3-dihydro-7H-dibenzo[de,h]quinolin-7-ones was determined using cyclic voltammetry in DMSO as solvent and rationalized by quantum chemical calculations using ab initio ...
    • Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells 
      Villena, Joan; Henríquez Luna, Mauricio; Torres Gómez, Vicente; Moraga, Francisco; Díaz Elizondo, Jessica; Arredondo, Cristian; Chiong Lay, Mario; Olea Azar, Claudio; Stutzin Schottlander, Andrés; Lavandero González, Sergio; Quest, Andrew F. G. (ELSEVIER SCIENCE INC, 2008-03-15)
      In lymphocytes, Fas activation leads to both apoptosis and necrosis, whereby the latter form of cell death is linked to delayed production of endogenous ceramide and is mimicked by exogenous administration of long- and ...
    • Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative ... 
      Jullian Matthaei, Carolina; Morales Montecinos, Javier; Zapata Torres, Gerald Amilcar; Aguilera, Benjamín; Rodríguez Borges, Jorge; Arán, Vicente J.; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-05-01)
      The slightly water-soluble 5-nitroindazole derivative (5-NI) and its inclusion with either beta-cyclodextrin (beta CD) or Heptakis (2,6-di-O-methyl)-beta- cyclodextrin (DM beta CD) were investigated. The stoichiometric ...
    • Chemical and biological properties of phenolics in wine: Analytical determinations and health benefits 
      Zúñiga López, María C.; Laurie, V. Felipe; Barriga González, Germán; Folch Cano, Christian; Fuentes, Jocelyn; Agosin Trumper, Eduardo; Olea Azar, Claudio (Bentham Science Publishers B.V., 2017)
      © 2017 Bentham Science Publishers. Since the early 1990s, a meaningful number of reports have been published supporting the idea that wines, especially reds, encompass a series of bioactive compounds, mainly phenolic ...
    • Chemical structure and biological properties of sulfated fucan from the sequential extraction of subAntarctic ... 
      Leal, D.; Mansilla, A.; Matsuhiro, B.; Moncada-Basualto, Mauricio; Lapier, M.; Maya Arango, Juan; Olea Azar, Claudio; De Borggraeve, W. M. (Elsevier Ltd, 2018)
      © 2018 Elsevier Ltd This work is related to the structural characterization of the sulfated polysaccharide from Lessonia sp and the study of its antioxidant and antiparasitic properties. Sequential extraction afforded ...
    • Comparative evaluation of the acceptor properties of quinone derivatized polypyridinic ligands 
      Norambuena V., Ester; Olea Azar, Claudio; Delgadillo, Alvaro; Barrera, Mauricio; Loeb, Bárbara (ELSEVIER SCIENCE BV, 2009-05-18)
      The reduction properties of four acceptor polipyridyl ligands modified with quinones were studied by different experimental methods, as cyclic voltammetry and ESR spectroscopy, and by theoretical calculations. ESR spectra ...
    • Comparative SCF MO studies for some histamine analogues as agonists of the H2 receptor of histamine 
      Olea Azar, Claudio; Parra Mouchet, Julia (Sociedad Chilena de Química, 1999)
      This paper presents SCF AM1 and CNDO/2 RF calculations of the potential energy surface of histamine monocation (HA) and the agonists 2-(4-thiazolyl)ethylamine (TIA) and 2-(4-oxazolyl)ethylamine (OXA). the similarity of ...
    • Comparative spectroscopic and electrochemical study of nitroindazoles: 3-Alcoxy, 3-hydroxy and 3-oxo derivatives 
      Rodríguez Borges, Jorge; Olea Azar, Claudio; Barriga, Germán; Folch, Christian; Gerpe, Alejandra; Cerecetto, Hugo; González, Mercedes (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the ...
    • Complexation of morin with three kinds of cyclodextrin - A thermodynamic and reactivity study 
      Jullian Matthaei, Carolina; Orosteguis, Teresita; Pérez Cruz, Fernanda; Sánchez, Paulina; Mendizábal Emaldía, Fernando; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-11-01)
      Properties of inclusion complexes between morin (M) and beta-cyclodextrin (beta CD), 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) and Heptakis (2,6-O-di methyl) beta-cycloclextrin (DM beta CD) such as aqueous solubility ...